Studies on amphotericin B pharmacokinetics. (2). Analysis of the elimination process.
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چکیده
منابع مشابه
Amphotericin B pharmacokinetics in humans.
The pharmacokinetics of amphotericin B were studied in two patients at the conclusion of long-term therapy for disseminated histoplasmosis. The distribution kinetics of this drug were adequately described by a three-compartment mamillary model with a total distribution volume averaging 4 liters/kg. The elimination phase half-life of amphotericin B was approximately 15 days, reflecting slow rele...
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چکیده ندارد.
15 صفحه اولPharmacokinetics of amphotericin B and flucytosine.
The absorption of flucytosine from the digestive tract is very good but minimal with amphotericin B. For this reason, amphotericin B has to be injected intravenously. Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin B, since the dose has to be increased slowly. Distribution of flucytosine in other body fluids is high, whereas with amphotericin B it is poor. ...
متن کاملPharmacokinetics of amphotericin B in children.
Amphotericin B is the most effective agent for the majority of systemic fungal infections but often causes toxicity, and specific dosage guidelines for amphotericin B in pediatric patients are lacking. The purpose of this study was to characterize the pharmacokinetics of amphotericin B in children. Twelve patients (mean age, 6.6 years; range, 4 months to 14 years) receiving amphotericin B, 0.68...
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ژورنال
عنوان ژورنال: Nippon Ishinkin Gakkai Zasshi
سال: 1990
ISSN: 0916-4804,1882-0476
DOI: 10.3314/jjmm.31.219